Self-driven web technologist and cross-platform solutions enthusiast with strong analytic mind. Interest in pattern recognition and integration between web platforms and databases. PhD and Engineering degrees in fields of chemistry / bioinformatics with a strong publication record in peer-reviewed journals. Java, Python & PHP programmer. Keen on rock music and rock climbing
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Implementation and development of ATLAS Beowulf type cluster network for nano-Electronic Design Automation in ToK4nEDA project
Beowulf Cluster widely-used term meaning independent computers combined into a unified system through software and networking based on commodity hardware, on a private system network. One of the main goals of ToK4nEDA project is Design of the advanced PC cluster of Beowulf type named ATLAS (Advanced Technology Laboratory Server) and its integration with local and European Grid Network (EUROGRID) for solving of large system of linear equations by direct (sparse matrices solvers) and iterative methods. The infrastructure will support industry and also other research and training projects related to ToK4nEDA such as Chameleon, Artic, Comson and EST.
The International Supercomputing Conference is the Europe’s premier HPC event. The attendance allows observing trends science and technology of High Performance Computing for whole next year. 2009 edition achieved record numbers of attendees and exhibitors, a level of success even more impressive given the international economic crisis. With its move to Hamburg, ISC’09 reached a significantly higher level of attendance, bringing 1,670 HPC industry leaders. Research labs demonstrated their scientific applications of supercomputing in most recent fields such us GPGPU accelerators, clouds and green computing. Furthermore, this, ISC’09 also welcomed several first-time exhibitors. The exhibition brought countless highlights such as the demo of both the IS5000 40 Gb/s infniband switches and low-latency 10 Gigabit Ethernet. The attendance on ISC’09 allows to anticipate future development of ATLAS system and to present current achievements’ of ToK4nEDA team. Jakub Paś Jakub Paś Ja
Structural genomics is the wide term which describes process of determination of structure representation of information in human genome and at present is limited almost exclusively on proteins. Although in common understanding genetic information means “genes and their encoded protein products”, thousands of human genes produce transcripts which are important in biological point of view but they do not necessarily produce proteins. Furthermore, even though the sequence of the human DNA is known by now, the meaning of the most of the sequences still remains unknown. It is very likely that a large amount of genes has been highly underestimated, mainly because the actual gene finders only work well for large, highly expressed, evolutionary conserved protein-coding genes. Most of those genome elements encode for RNA from which transfer and ribosomal RNAs are the classical examples. But beside these well-known molecules there is a vast unknown world of tiny RNAs that might play a crucial r
Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. Many thousands of linear motif instances, most notably phosphorylation sites, have now been reported. Although clearly very abundant, linear motifs are difficult to predict de novo in protein sequences due to the difficulty of obtaining robust statistical assessments. The ELM resource at http://elm.eu.org/ provides an expanding knowledge base, currently covering 146 known motifs, with annotation that includes >1300 experimentally reported instances. ELM is also an exploratory tool for suggesting new candidates of known linear motifs in proteins of interest. Information about protein domains, protein structure and native disorder, cellular and taxonomic contexts is used to reduce or deprecate false positive matches. Results are graphically displayed in a 'Bar