Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. Many thousands of linear motif instances, most notably phosphorylation sites, have now been reported. Although clearly very abundant, linear motifs are difficult to predict de novo in protein sequences due to the difficulty of obtaining robust statistical assessments. The ELM resource at http://elm.eu.org/ provides an expanding knowledge base, currently covering 146 known motifs, with annotation that includes >1300 experimentally reported instances. ELM is also an exploratory tool for suggesting new candidates of known linear motifs in proteins of interest. Information about protein domains, protein structure and native disorder, cellular and taxonomic contexts is used to reduce or deprecate false positive matches. Results are graphically displayed in a 'Bar Code' format, which also displays known instances from homologous proteins through a novel 'Instance Mapper' protocol based on PHI-BLAST. ELM server output provides links to the ELM annotation as well as to a number of remote resources. Using the links, researchers can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation.
Overview Continuous integration (CI) is a development practice which allows testing, building and checking the quality of the application in automated way without manual developer intervention. It requires developers to integrate code into a shared repository several times a day or every commit/merge to the given branch of the repository. Each check-in is then verified by an automated build, allowing teams to detect problems early. While PHP Continuous Integration (PHPCI) does not require the the code compilation as build” one can understand the set of task like testing and quality checks which are performed in timely manner or when the certain conditions are met. PHPCI can be performed on Jenkins Server. The detailed description of jenkins server configuration in is presented here. PHPCI requires PHing package which can be provided into application by Composer.