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ELM: the status of the 2010 eukaryotic linear motif resource

Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through protein modifications at linear motifs. Many thousands of linear motif instances, most notably phosphorylation sites, have now been reported. Although clearly very abundant, linear motifs are difficult to predict de novo in protein sequences due to the difficulty of obtaining robust statistical assessments. The ELM resource at http://elm.eu.org/ provides an expanding knowledge base, currently covering 146 known motifs, with annotation that includes >1300 experimentally reported instances. ELM is also an exploratory tool for suggesting new candidates of known linear motifs in proteins of interest. Information about protein domains, protein structure and native disorder, cellular and taxonomic contexts is used to reduce or deprecate false positive matches. Results are graphically displayed in a 'Bar Code' format, which also displays known instances from homologous proteins through a novel 'Instance Mapper' protocol based on PHI-BLAST. ELM server output provides links to the ELM annotation as well as to a number of remote resources. Using the links, researchers can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation.
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International Supercomputing Conference, Dresden, Germany

ISC has evolved into a high-powered international conference and exhibition that gives its attendees a global perspective on the cutting edge of HPC. As always, our conference program tackles hot HPC topics; this year, for example, we will have a panel session on “Green Computing”, a topic that was almost unknown just two years ago. ISC’s focus on future trends and developments can also be seen in this year’s keynote presentation by Prof. Dr. Satoshi Matsuoka of the Tokyo Institute of Technology, Japan, who will discuss “Everybody Supercomputes in the Next Generation Cyber-Science Infrastructure”.
I look forward to seeing you in Dresden.