Glioblastoma multiforme (GBM) accounts for approximately 12-15% of intracranial neoplasms. The GBM remains refractory to therapy because of tumor heterogenity, local invasion, and non-uniform vascular permeability to drugs. Patients with GBM have the median survival of approximately 8-10 months, and for those cases where tumor recurs, the average time of tumor progression after therapy is only eight weeks. A combination of different treatment modes as surgery and chemo- or/and radiotherapy extend survival only for a short time, if any. Recently, tenascin-C (TN-C) as a dominant epitope in glioblastoma has been discovered. Tenascin-C is a multidomain large extracellular matrix glycoprotein composed of six monomers. The size of tenascin-C monomers (180-250kDa) varies as a result of an alternative splicing of the fibronectin repeats at the pre-mRNA level. For the first time we applied bioinformatic and molecular modeling procedures, for detailed analysis of the organization of tenascin-C and we performed bioinformatic analysis of tenascin-C gene. We showed the higher level of tenascin-C in the human tumor tissues: brain, intestine and breast. These results suggested a new role of tenascin-C as the potential tumor marker and drug target.
Overview Continuous integration (CI) is a development practice which allows testing, building and checking the quality of the application in automated way without manual developer intervention. It requires developers to integrate code into a shared repository several times a day or every commit/merge to the given branch of the repository. Each check-in is then verified by an automated build, allowing teams to detect problems early. While PHP Continuous Integration (PHPCI) does not require the the code compilation as build” one can understand the set of task like testing and quality checks which are performed in timely manner or when the certain conditions are met. PHPCI can be performed on Jenkins Server. The detailed description of jenkins server configuration in is presented here. PHPCI requires PHing package which can be provided into application by Composer.